Two Concurrent Chromosomal Aberrations Involving Three-way t(3;21;8)(p21;q22;q22) and Two-way t(2;11)(q31;p15) Translocations in a Case of de novo Acute Myeloid Leukemia.
- Author:
Gyun Cheol PARK
1
;
Eun Hae CHO
;
Sung Ho KANG
;
Sook Jin JANG
;
Dae Soo MOON
;
Geon PARK
Author Information
- Publication Type:Case Report
- Keywords: Acute myeloid leukemia; RUNX1-RUNX1T1; Variant translocation
- MeSH: Chromosome Aberrations*; Diagnosis; Humans; Leukemia, Myeloid, Acute*; Polymerase Chain Reaction; Recurrence; Reverse Transcription
- From:Laboratory Medicine Online 2016;6(4):246-249
- CountryRepublic of Korea
- Language:Korean
- Abstract: One of the most frequent structural chromosomal anomaly is t(8;21)(q22;q22) that occurs in approximately 5-15% of all acute myeloid leukemia (AML). However, t(3;21)(p21;q22) and t(2;11)(q31;p15) translocations are rarely reported in AML. Here, we report a unique case of AML with two translocations, t(3;21;8)(p21;q22;q22) and t(2;11)(q31;p15). Using multiplex reverse transcription polymerase chain reaction, we identified a RUNX1-RUNX1T1 fusion gene. Following a second relapse, the patient did not respond to therapy and died 55 months following the first diagnosis. We believe that this is the first case describing concurrent chromosomal aberrations involving three-way t(3;21;8) and two-way t(2;11) translocations in de novo acute myeloid leukemia.
