A Case of ABO Discrepancy due to Anti-IH.
- Author:
Yangsoon LEE
1
;
Sang Guk LEE
;
Sinyoung KIM
;
Eun Jung BAEK
;
Hyun Ok KIM
Author Information
1. Department of Laboratory Medicine, Yonsei Uinversity Health System, Korea. hyunok1019@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
ABO discrepancy;
Anti-IH;
Universal donor blood
- MeSH:
Aged;
Agglutination;
Blood Cells;
Female;
Genotype;
Humans;
Hypertension;
Kidney Failure, Chronic;
Mass Screening;
Sensitivity and Specificity;
Tissue Donors;
Wrist
- From:Korean Journal of Blood Transfusion
2007;18(1):66-69
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The patient was a 70-year-old woman with hypertension and end stage renal disease, and she presented with left wrist pain due to falling a day before admission. On admission, laboratory testing revealed a hemoglobin level of 6.7 g/dL, and a physician ordered 2 units of packed RBCs. She had never received a RBC transfusion in the past. The ABO grouping showed a discrepancy between the cell type AB and serum type O, and the irregular antibody screening was negative. Crossmatchings with group AB and group O RBCs were incompatible. Anti-I, which is a cold antibody, was inferred because the degree of agglutination was decreased after warming. However, crossmatching with group O RBCs, which are the universal donor blood, was positive and the anti-IH was considered to be the specificity of the irregular antibody. The patient's serum did not react with group O cord (i) blood cells and anti-I was then considered. The genotype of this patient was AB, and it was inferred that the ABO discrepancy was due to anti-IH.
