Photodynamic Therapy of Choroidal Neovascularization in Age-Related Macular Degeneration with Verteporfin: An Analysis of 10 Years of Clinical Results.
10.3341/jkos.2012.53.1.59
- Author:
Doo Young CHO
1
;
So Hyun BAE
;
Jae Ryong HAN
;
Ha Kyoung KIM
;
Woo Ho NAM
Author Information
1. Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. wooho.nam@gmail.com
- Publication Type:Original Article
- Keywords:
Age-related macular degeneration (AMD);
Choroidal neovascularization (CNV);
Photodynamic therapy (PDT)
- MeSH:
Choroid;
Choroidal Neovascularization;
Eye;
Humans;
Macular Degeneration;
Photochemotherapy;
Prognosis;
Triazenes;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2012;53(1):59-67
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To analyze the long-term results of photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD). METHODS: The clinical data of patients treated with photodynamic therapy for exudative age-related macular degeneration between April 2000 and December 2000 were analyzed. Patients were followed-up for at least 10 years after PDT. RESULTS: Twenty-nine eyes of 29 patients were enrolled. Mean visual acuity on the logarithm of the minimum angle of resolution (log MAR) scale was 0.78 +/- 0.34 at baseline, 1.01 +/- 0.42 at 60 months, and 1.02 +/- 0.41 at 120 months. Predominantly classic, minimally classic, and occult without classic choroidal neovascularization was noted in 51.7%, 17.2%, and 31.1% of patients, respectively. Visual acuity was improved by 1 or more lines in 27.6% of patients and was unchanged in 20.7% of patients, while 51.7% of patients had lost 1 or more lines of visual acuity by 120 months. Baseline visual acuity and age were associated with the final visual prognosis (p < 0.05). Four patients developed neovascular AMD in the contralateral eye. CONCLUSIONS: PDT is safe and effective for neovascular AMD. However, AMD can recur at any time and thus patients should be followed-up for a long period of time.
