The Effect of Uric Acid on GFR in Early Period after Kidney Transplantation.
- Author:
Sun Young PARK
1
;
Dong Ki KIM
;
Jae Hyun CHANG
;
Hyun Wook KIM
;
Eun Young KIM
;
Jung Tak PARK
;
Tae Ik CHANG
;
Tae Hyun YOO
;
Beom Seok KIM
;
Shin Wook KANG
;
Ho Yung LEE
;
Dae Suk HAN
;
Myoung Soo KIM
;
Soon Il KIM
;
Kyu Hun CHOI
Author Information
1. Department of Internal Medicine, College of Medicine Yonsei University, Seoul, Korea. khchoi6@yuhs.ac
- Publication Type:Original Article
- Keywords:
Uric acid;
Kidney transplantation;
Glomerular filtration rate
- MeSH:
Academic Medical Centers;
Cardiovascular Diseases;
Follow-Up Studies;
Glomerular Filtration Rate;
Graft Survival;
Humans;
Hyperuricemia;
Kaplan-Meier Estimate;
Kidney;
Kidney Transplantation;
Risk Factors;
Transplants;
Uric Acid
- From:Korean Journal of Nephrology
2008;27(6):712-719
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Hyperuricemia is a common complication occurring shortly after kidney transplantation. Although increased uric acid level is a risk factor for cardiovascular disease and mortality, the relationship between uric acid level and graft function after transplantation has been a controversial issue. Therefore, we investigated the effects of uric acid on glomerular filtration rate (GFR) and graft survival in the early periods of kidney transplantation. METHODS: Data were collected from 245 patients who underwent kidney transplantation between 2002 and 2004 at Yonsei University Medical Center. Uric acid level and estimated GFR were measured monthly during the first 6 months and then yearly for 3 years. RESULTS: The mean age of the study population was 40.2+/-11.7 years. The proportion of patients with hyperuricemia (uric acid < or =6.8 mg/dL) showed increment during the 3 year follow up. Increased serum uric acid level showed a negative correlation with estimated GFR during the initial 6 months after transplantation (r=-0.026, p<0.05). In Kaplan-Meier analysis, patients with a mean uric acid level higher than 6.8 mg/dL during the first 6 months showed a lower cumulative graft survival during the consecutive 3 years compared to patients with a uric acid level lower than 6.8 mg/dL (HR 1.7, p=0.003). CONCLUSION: Uric acid levels were associated with the changes of GFR in the initial 6 months of kidney transplantation, and the hyperuricemia during the early stages of transplantation might influence the long term graft survival.
