A Case of Acute Interstitial Nephritis Complicated with Continuous Rifampin Therapy.
- Author:
Hyun Jung KIM
1
;
Jeong Min CHA
;
Duk Eun JUNG
;
Ji Eun LEE
;
Yu Min LEE
;
Jin Ho SHIN
;
Seung Jae BYUN
;
Ju Hung SONG
;
Seon Ho AHN
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. ashneph@wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Rifampin;
Interstitial nephritis;
Acute renal failure
- MeSH:
Acute Kidney Injury;
Biopsy;
Creatinine;
Dyspnea;
Edema;
Humans;
Male;
Nephritis, Interstitial;
Renal Insufficiency;
Rifampin
- From:Korean Journal of Nephrology
2008;27(6):738-742
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute renal failure caused by rifampin typically occurs on intermittent administration or reintroduction of the drug. However, acute kidney injury (AKI) due to rifampin has been rarely reported to occur in patients receiving a continuous rifampin therapy. We have experienced a case of acute interstitial nephritis during the first course of standard anti-tuberculous therapy, including continuous rifampin therapy in daily dose. Forty-five-year-old male, who had been being treated with anti-tuberculous medication including rifampin (600 mg/day), was admitted to our hospital because of generalized edema and dyspnea by acute renal failure. His past medical history was unremarkable. Since the creatinine level was still elevated in 10 days after cessation of rifampin, we performed renal biopsy. The renal pathologic findings revealed acute interstitial nephritis. After that, the patient symptom was relieved and serum creatinine level was decreased without specific therapy. The renal function was recovered at 1 month after withdrawal of rifampin. We report a case of acute interstitial nephritis complicated with the first daily rifampin therapy, along with the review of literature.
