Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Fatty Liver Disease.
- Author:
Dong Min LEE
1
;
Seung Ok LEE
;
Byoung Sik MUN
;
Heok Soo AHN
;
Hye Young PARK
;
Hye Soo LEE
;
Dae Ghon KIM
Author Information
1. Department of Internal Medicine, Chonbuk National University College of Medicine, Chonju, Korea. daeghonkim@moak.chonbuk.ac.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Fatty liver;
Apolipoprotein E gene;
Polymorphism;
Body mass index
- MeSH:
Adult;
Aged;
Apolipoproteins E/*genetics;
English Abstract;
Fatty Liver/*genetics;
Female;
Gene Frequency;
Human;
Male;
Middle Aged;
*Polymorphism (Genetics)
- From:The Korean Journal of Hepatology
2002;8(4):355-362
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Apolipoprotein E (Apo E) is important in plasma lipid metabolism and is a component of several plasma lipoprotein-lipid particles. Three major Apo E isoforms are encoded by three common allelic forms, epsilon2, epsilon3, and epsilon4 at the APO E locus. The goal of this study was to examine the association between polymorphisms in the apolipoprotein E gene (APOE) and fatty liver disease. METHODS: We examined the distribution of APOE alleles from 116 fatty liver patients and 50 controls in Korea. RESULTS: The frequencies of APOE alleles in fatty liver patients were 6.5% in epsilon2, 85.7% in epsilon3 and 7.8% in epsilon4. The corresponding frequencies in control subjects were 4.0% in epsilon2, 91.0% in epsilon3 and 5.0% in epsilon4. There were no significant differences in the distribution of APOE genotypes between fatty liver patients and controls. APOE epsilon2 and epsilon4 allele frequencies in fatty liver patients were more than those in controls. However, there was no significant differences in APOE epsilon2 and epsilon4 allele frequencies. CONCLUSIONS: These results suggest that APOE alleles seem not to be directly associated with the pathogenesis of fatty liver disease.
