Botulinum A Toxin Treatment of Hemifacial Spasm: The Dose-response Relationship in Orbicularis Oculi.
- Author:
Bong Ae WIE
1
;
Kang Woo LEE
;
Hojin MYUNG
;
Joo Yong KIM
;
Jae Kyu ROH
;
Seung Bong HONG
;
Sang Yun KIM
;
Joung Ho RHA
;
Il Keun LEE
;
Jae Hong LEE
;
Seong Ho PARK
;
Sang Bok LEE
;
Chin Sang CHUNG
Author Information
1. Department of Neurology, College of Medicine, Seoul National University.
- Publication Type:Original Article
- MeSH:
Botulinum Toxins, Type A*;
Hemifacial Spasm*;
Humans;
Strikes, Employee
- From:Journal of the Korean Neurological Association
1992;10(2):155-161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Forty-one patients with hemifacial spasm received botulinum A toxin in total 73 visits. In 68 of 73 visits(93%), substantial improvement with peak effect(change in severity of hemifacial spasm 22 ) was obtained, with a mean total dose of 12.5 units. Mean severity of hemifacial spasm before and after treatrnent were 3.8 and 1.1 respectively on a 0-5 scale. Mean muscle dose of orbicularis oculi was 9.0 units There was a significant association between muscle dose and post-treatment weakness of orbicularis oculi(Spearman correlation coefficient, 0.42691). There was also a striking and significant association between post-treatment weakness of orbicularis oculi and peak effect(Spearman correlation coefficient, 0.74883). Lagophthalmos occurred only in 2 of 28 visits (7%) who received lesser than 10.0 units for orbicularis oculi as compard to 22% in the higher dose group. But peak effects showed no significant difference between the two groups(p =O.I30). We suggest that the occurrence of lagophthalmos can be reduced with the dose lesser than 10.0 units for orbicularis oculi, maintaining the significant effect.
