Effects of IL-7 on human lymphocytes.
- Author:
Heung Sik KIM
1
;
Chin Moo KANG
;
Harry FINDLEY
;
Abdel H RAGAB
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Interleukin-7; Leukemia; Lymphocyte; 3H-Thymidine incorporation
- MeSH: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Interleukin-4/pharmacology; Interleukin-7/*pharmacology; Leukemia, Myeloid, Acute/*immunology; Leukemia-Lymphoma, Adult T-Cell/*immunology; Lymphocytes/drug effects/*immunology; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma/*immunology; Tumor Cells, Cultured
- From:Journal of Korean Medical Science 1993;8(2):93-98
- CountryRepublic of Korea
- Language:English
- Abstract: Interleukin-7 (IL-7) is known as a growth factor for pre B-cell and mature T-cells in human. But in leukemic cells, IL-7 effect is variously reported. To investigate the effect of IL-7 on the cells of childhood acute leukemia we used 3H-Thymidine assay. Twelve Acute lymphoblastic leukemia (ALL), seven T-ALL and three Acute myelogenous leukemia (AML) were involved in this study. Two out of twelve ALL and three out of seven T-ALL bone marrow (BM) cells were stimulated by IL-7 in 3H-Thymidine incorporation. In normal and AML BM cells, IL-7 had no stimulatory activity as in various leukemic cell lines. Two normal peripheral blood T-cells responded to IL-7 dose dependently. We have seen the effect of IL-7 to stimulate T-lineage cells but, for precise conclusion, further study using more purified samples will be needed.
