Cervical intraepithelial neoplasia 3, coinfected with HPV-16 and -18: case report.
10.3346/jkms.1993.8.2.162
- Author:
Jong Sup PARK
1
;
Sung Eun NAMKOONG
;
Joon Mo LEE
;
Eun Jung KIM
;
Yong Hun CHEE
;
Gu Taek HAN
;
Seung Jo KIM
Author Information
1. Department of Obstetrics and Gynecology, Catholic University Medical College, Seoul, Korea.
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Human papillomavirus (HPV);
in situ hybridization;
cervical intraepithelial neoplasia (CIN)
- MeSH:
Adult;
Cervical Intraepithelial Neoplasia/*microbiology;
Cervix Uteri/microbiology;
Female;
Humans;
In Situ Hybridization;
Papillomaviridae/genetics/*isolation & purification;
Papillomavirus Infections/*microbiology;
Tumor Virus Infections/complications/*microbiology;
Uterine Cervical Neoplasms/*microbiology
- From:Journal of Korean Medical Science
1993;8(2):162-165
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recently, detection of human papillomavirus (HPV)mRNA expression was made possible by in situ hybridization. We described a patient with cervical intraepithelial neoplasia (CIN) 3, showing a distinctive and rare form of co-infection with HPV type 16 and 18. HPV-16 was detected in high grade squamous intraepithelial neoplastic lesion (CIN 3) and HPV-18 was in low grade lesion just adjacent to the HPV-16 infected area. This case suggests that HPV infection may be one of the most responsible causative agents producing malignant transformation and two distinctive HPV types can also simultaneously infect the squamous epithelium of the uterine cervix.
