Diffusion-Weighted MR Imaging in Biopsy-Proven Creutzfeldt-Jakob Disease.
- Author:
Hyo Cheol KIM
1
;
Kee Hyun CHANG
;
In Chan SONG
;
Sang Hyun LEE
;
Bae Ju KWON
;
Moon Hee HAN
;
Sang Yun KIM
Author Information
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords: Brain, infection; Creutzfeldt-Jakob disease; Dementia; Magnetic resonance (MR), diffusion study
- MeSH: Adult; Aged; Biopsy; Comparative Study; Creutzfeldt-Jakob Syndrome/diagnosis/*pathology; Female; Human; Magnetic Resonance Imaging/*methods; Male; Middle Age; Retrospective Studies; Sensitivity and Specificity; Support, Non-U.S. Gov't
- From:Korean Journal of Radiology 2001;2(4):192-196
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To compare conventional and diffusion-weighted MR imaging in terms of their depiction of the abnormalities occurring in Creutzfeldt-Jakob disease. MATERIALS AND METHODS: We retrospectively analyzed the findings of conventional (T2-weighted and fluid-attenuated inversion recovery) and diffusion-weighted MR imaging in four patients with biopsy-proven Creutzfeldt-Jakob disease. The signal intensity of the lesion was classified by visual assessment as markedly high, slightly high, or isointense, relative to normal brain parenchyma. RESULTS: Both conventional and diffusion-weighted MR images demonstrated bilateral high signal intensity in the basal ganglia in all four patients. Cortical lesions were observed on diffusion-weighted MR images in all four, and on fluid-attenuated inversion recovery MR images in one, but in no patient on T2-weighted images. Conventional MR images showed slightly high signal intensity in all lesions, while diffusion-weighted images showed markedly high signal intensity in most. CONCLUSION: Diffusion-weighted MR imaging is more sensitive than its conventional counterpart in the depiction of Creutzfeldt-Jakob disease, and permits better detection of the lesion in both the cerebral cortices and basal ganglia.
