Detection of Malignant Primary Hepatic Neoplasms with Gadobenate Dimeglumine (Gd-BOPTA) Enhanced T1-Weighted Hepatocyte Phase MR Imaging: Results of Off-site Blinded Review in a Phase-II Multicenter Trial.
- Author:
Constantino S PENA
1
;
Sanjay SAINI
;
Richard L BARON
;
Bernd A HAMM
;
Giovanni MORANA
;
Roberto CAUDANA
;
Andrea GIOVAGNONI
;
Andrea VILLA
;
Alessandro CARRIERO
;
Didier MATHIEU
;
Michael W BOURNE
;
Miles A KIRCHIN
;
Gianpaolo PIROVANO
;
Alberto SPINAZZI
Author Information
- Publication Type:Original Article ; Clinical Trial ; Clinical Trial, Phase II ; Multicenter Study
- Keywords: Liver neoplasms, MR; Liver neoplasms, diagnosis; Magnetic resonance (MR), contrast media
- MeSH: Adenoma, Liver Cell/*diagnosis; Adult; Aged; *Contrast Media; Female; Human; Image Enhancement; Liver Neoplasms/*diagnosis; Magnetic Resonance Imaging/*methods; Male; Meglumine/*analogs & derivatives/*diagnostic use; Middle Age; Organometallic Compounds/*diagnostic use
- From:Korean Journal of Radiology 2001;2(4):210-215
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: To investigate the efficacy of gadobenate dimeglumine (Gd-BOPTA) enhanced MR imaging for the detection of liver lesions in patients with primary malignant hepatic neoplasms. MATERIALS AND METHODS: Thirty-one patients with histologically proven primary malignancy of the liver were evaluated before and after administration of Gd-BOPTA at dose 0.05 or 0.10 mmol/kg. T1-weighted spin echo (T1W-SE) and gradient echo (T1W-GRE) images were evaluated for lesion number, location, size and confidence by three off-site independent reviewers and the findings were compared to reference standard imaging (intraoperative ultrasound, computed tomography during arterial portography or lipiodol computed tomography). Results were analyzed for significance using a two-sided McNemar's test. RESULTS: More lesions were identified on Gd-BOPTA enhanced images than on unenhanced images and there was no significant difference in lesion detection between either concentration. The largest benefit was in detection of lesions under 1 cm in size (7 to 21, 9 to 15, 16 to 18 for reviewers A, B, C respectively). In 68% of the patients with more than one lesion, Gd-BOPTA increased the number of lesions detected. CONCLUSION: Liver MR imaging after Gd-BOPTA increases the detection of liver lesions in patients with primary malignant hepatic neoplasm.
