Effect of Ketamine on the Echoic Memory Process: The Mismatch Negativity and Glutamate Receptor System in Schizophrenia.
- Author:
Tak YOUN
1
;
Kyung Heup AHN
;
Ji Soo PAE
;
Myung Sun KIM
;
Jae Jin KIM
;
Jun Soo KWON
Author Information
1. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. kwonjs@plaza.xnu.ac.kr
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Information process;
NMDA receptor;
Mismatch negativity;
Echoic memory
- MeSH:
Brain;
Brief Psychiatric Rating Scale;
Electroencephalography;
Glutamic Acid*;
Humans;
Ketamine*;
Memory*;
N-Methylaspartate;
Psychophysiology;
Receptors, Glutamate*;
Receptors, N-Methyl-D-Aspartate;
Schizophrenia*
- From:Korean Journal of Psychopharmacology
2001;12(4):322-327
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The abnormality of mismatch negativity (MMN) in schizophrenia is thought to be associated with perceptional disturbance and cognitive dysfunction. And the antagonists of the N-methyl-D-aspartate (NMDA) receptors, ketamine, can induce anomalies of psychophysiology and cognitive function as those of schizophrenia. In order to explore the role of NMDA receptors on echoic memory system, MMN under ketamine administration was analyzed. METHODS: MMNs of Healthy 12 subjects under sub-anesthetic dose (0.65 mg/kg/hr) of ketamine administration in placebo-controlled design were recorded by 128 channel EEG. Brief Psychiatric Rating Scale (BPRS) change was also evaluated. RESULTS: BPRS score was significantly increased by ketamine administration (t=-6.655, p<0.001). Ketamine induced significant decrease in MMN amplitudes (Fz, t=-2.572, p=0.026). Neither MMN amplitude under placebo administration nor MMN latencies under ketamine administration and placebo was changed significantly. CONCLUSION: Ketamine induced echoic memory dysfunction in healthy subjects, which is usually found in schizophrenic patients. Consequently, reduced glutamatergic activity in brain could be involved some early processes of the memory dysfunction in schizophrenia.
