Intermuscular Adipose Tissue Content and Intramyocellular Lipid Fatty Acid Saturation Are Associated with Glucose Homeostasis in Middle-Aged and Older Adults.
10.3803/EnM.2017.32.2.257
- Author:
Jung Eun KIM
1
;
Keagan DUNVILLE
;
Junjie LI
;
Ji Xin CHENG
;
Travis B CONLEY
;
Cortni S COUTURE
;
Wayne W CAMPBELL
Author Information
1. Department of Nutrition Science, Purdue University College of Health and Human Sciences, West Lafayette, IN, USA. campbellw@purdue.edu
- Publication Type:Original Article
- Keywords:
Glucose homeostasis;
Intermuscular adipose tissue;
Intramyocellular lipid;
Overweight and obesity;
Middle-aged and older adults
- MeSH:
Adipose Tissue*;
Adult*;
Body Mass Index;
Fasting;
Glucose*;
Homeostasis*;
Humans;
Insulin;
Insulin Resistance;
Magnetic Resonance Imaging;
Male;
Microscopy;
Muscle Cells;
Obesity;
Overweight;
Quadriceps Muscle;
Thigh
- From:Endocrinology and Metabolism
2017;32(2):257-264
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Insulin resistance is associated with the higher content of intermuscular adipose tissue (IMAT) and the saturation of intramyocellular lipid (IMCL), but a paucity of data exist in humans. This study examined associations among IMAT content, IMCL saturation, and fasting glucose concentration in middle-aged and older adults with overweight or obesity. METHODS: Seventy-five subjects (26 males, 49 females) were recruited and thigh muscle and IMAT were assessed using magnetic resonance imaging. Vastus lateralis tissue was acquired from a subset of nine subjects and IMCL content and saturation were assessed using nonlinear dual complex microscopy. RESULTS: The characteristics of the 75 subjects were as follows: age 59±11 years, body mass index 30±5 kg/m², fasting glucose concentration 5.2±0.5 mmol/L, fasting insulin concentration 12.2±7.3 µU/mL, fasting homeostatic model assessment of insulin resistance (HOMA-IR) 2.9±2.0 (mean±SD). IMAT to muscle tissue (MT) volume ratio was positively associated with the saturated fatty acid to unsaturated fatty acid ratio in IMCL. IMAT:MT was positively associated with fasting glucose concentration and HOMA-IR. IMCL saturation was positively associated with fasting glucose concentration while muscle cell area, IMCL area, and % IMCL in muscle cell were not associated with fasting glucose concentration. CONCLUSION: These results indicate that higher intermuscular fat content and IMCL saturation may impact fasting glucose concentration in middle-aged and older adults with overweight or obesity. The centralization of adipose tissue in the appendicular region of the body may promote insulin resistance.
