Clinical Survey of 10 Cases of Leber's Optic atrephy Among 3 Families.
- Author:
Sang Min KIM
1
;
Jin Hyoung YOO
Author Information
1. Eye Department, Catholic Medical College, Korea.
- Publication Type:Original Article
- MeSH:
Age of Onset;
Diagnosis;
Family Characteristics;
Female;
Heredity;
Humans;
Incidence;
Korea;
Male;
Neurologic Examination;
Orbit;
Pallor;
Pedigree;
Prognosis;
Retinal Vessels;
Scotoma;
Skull;
Visual Acuity;
Visual Fields
- From:Journal of the Korean Ophthalmological Society
1965;6(1):29-34
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Since it had not been possible to find any formal report on this disease in Korea, we had chance to examine and to make accurate diagnosis, so that we would like to report 10 calles among 3 families. Throughout the literature, the age of onset, the incidence, the mode of heredity, the etiology, the clinical picture, the prognosis, and the treatment were discussed. The results of this survey are as followings. 1. There were 5 males and 5 females in this material. This sex incidence showed rather similar with Japanese's than European's and American's. 2. As to the incidence of age of onset, Case I and III were between 15-22 years old, but Case II were between 6-8 years old. 3. As to the visual acuity, most patients had from H.M. to 0.1 (20/200), and most patients were who associated with the color disturbance. 4. The ophthalmoscopic finding revealed only total or temporal pallor on the disc, otherwise normal macula and retinal vessels. 5. Visual field changes showed central scotoma in all cases which were examined. 6. Various laboratory examinations, X-ray examinations for skull and orbit, neurological examination, etc., showed no significant pathological finding in cases which were examined. 7. As to the mode of heredity, those three families revealed not a typical sex-linked recessive form, as far as we could observe in two generations of the pedigree.
