Relationship Between Serum Concentrations of Organochlorine Pesticides and Metabolic Syndrome Among Non-Diabetic Adults.
10.3961/jpmph.2010.43.1.1
- Author:
Sun Kyun PARK
1
;
Hyo Kyung SON
;
Sung Kook LEE
;
Jung Ho KANG
;
Yoon Seok CHANG
;
David R JACOBS
;
Duk Hee LEE
Author Information
1. Department of Preventive Medicine, School of Medicine, Kyungpook National University, Korea. lee_dh@knu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Organochlorine compounds;
Environmental pollutants;
Persistent organic pollutants;
Metabolic syndrome X;
Insulin resistance;
Obesity
- From:Journal of Preventive Medicine and Public Health
2010;43(1):1-8
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes. METHODS: Among subjects who participated in a community-based health survey, 50 non-diabetic subjects with metabolic syndrome and 50 normal controls were selected. Insulin resistance was measured by the homeostasis model assessment (HOMA-IR). Eight OCPs were selected. RESULTS: After adjusting for confounders except for body mass index (BMI), beta-hexachlorocyclohexane (beta-HCH) and heptachlor epoxide were positively associated with metabolic syndrome. Odds ratios across tertiles of beta-HCH and heptachlor epoxide were 1.0, 3.2 and 4.4, and 1.0, 4.0 and 6.0, respectively (p for trend = 0.01 and <0.01). After additional adjustment for body mass index (BMI), heptachlor epoxide still showed an increasing trend with adjusted odds ratios of 1.0, 4.1, and 4.6 (p for trend = 0.10). When the five components of metabolic syndrome (with the definition of high fasting glucose (> or =100 mg/dL)) were separately analyzed, all components were positively, but not significantly, associated with heptachlor epoxide. As the serum concentration of heptachlor epoxide increased, HOMA-IR increased significantly in subjects with metabolic syndrome even after adjusting for BMI (p value <0.05 and <0.01). CONCLUSIONS: Despite the small sample size, this study suggests that the background exposure to some OCPs may be associated with metabolic syndrome.
