Mucosal dendritic cells shape mucosal immunity.
- Author:
Sun Young CHANG
1
;
Hyun Jeong KO
;
Mi Na KWEON
Author Information
- Publication Type:Research Support, Non-U.S. Gov't ; Review
- Keywords: antigen capture; helper T-cell subset; mucosal dendritic cells; mucosal vaccine; secretory IgA
- MeSH: Animals; Dendritic Cells/*immunology/metabolism; Humans; Immunity, Mucosal; Intestinal Mucosa/cytology/*immunology; T-Lymphocytes, Helper-Inducer/immunology
- From:Experimental & Molecular Medicine 2014;46(3):e84-
- CountryRepublic of Korea
- Language:English
- Abstract: Dendritic cells (DCs) are key modulators that shape the immune system. In mucosal tissues, DCs act as surveillance systems to sense infection and also function as professional antigen-presenting cells that stimulate the differentiation of naive T and B cells. On the basis of their molecular expression, DCs can be divided into several subsets with unique functions. In this review, we focus on intestinal DC subsets and their function in bridging the innate signaling and adaptive immune systems to maintain the homeostasis of the intestinal immune environment. We also review the current strategies for manipulating mucosal DCs for the development of efficient mucosal vaccines to protect against infectious diseases.
