Synthesis and antifungal properties of m- and o-phenylendithiourea
- Author:
Phuong Truong
- Publication Type:Journal Article
- Keywords:
phenylendithiourea
- MeSH:
Phenylenediamines;
3-phenylenediamine;
1,2-diaminobenzene;
diphenylthiourea
- From:Pharmaceutical Journal
1999;370(8):13-15
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
O- and m-phenylen diamin obtained by nitration and reduction of aniline and nitrobenzene. From amin compounds and by dithiocarbamat method synthesized isothiocyanat derivatives: Condensation of phenylendiisothiocyanat derivatives with amine compounds (p-aminosalicylic acid, p-aminobenzoic acid and their derivatives) to get 11 dithiourea derivatives. The purity of the products were controlled by the layer chromatography. The structures of them were determined by elemental analysis and IR spectroscopy, 1HNMR. The study indicated that all of them have strong effect on fungal strains except Candida albicans, Aspergillus niger and Aspergillus flavus. Some are stronger than ketoconazol.
