The relationship between serum adiponectin and inflammatory cytokines in obese Korean juveniles.
10.3345/kjp.2014.57.12.533
- Author:
Sung Hwan BYUN
1
;
Eun Byul KWON
;
Se Young KIM
Author Information
1. Department of Pediatrics, Bundang Jesaeng Hospital, Seongnam, Korea. odajulia@dmc.or.kr
- Publication Type:Original Article
- Keywords:
Adiponectin;
Intercellular adhesion molecule-1;
CD40 ligand;
P-selectin
- MeSH:
Adiponectin*;
Adolescent;
Adult;
Alanine Transaminase;
Aspartate Aminotransferases;
Atherosclerosis;
Body Mass Index;
CD40 Ligand;
Child;
Cytokines*;
Glucose;
Humans;
Inflammation Mediators;
Insulin;
Intercellular Adhesion Molecule-1;
Obesity;
P-Selectin
- From:Korean Journal of Pediatrics
2014;57(12):533-537
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Obesity is related to systemic inflammatory processes causing cardiovascular complications. Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), P-selectin are newly described mediators of inflammation and have a significant effect in atherosclerosis. Adiponectin has shown anti-inflammatory effects in adults. The aim of this study was to evaluate the relationship between adiponectin and inflammatory mediators in children and adolescents. METHODS: Fifty children or adolescents, twenty two with a body mass index (BMI) over 95th percentile, and twenty eight with a BMI below 75th percentile were included in the study. Serum soluble ICAM-1 (sICAM-1), P-selectin, CD40L, lipid profiles, aspartate aminotransferase, alanine aminotransferase, glucose and insulin were measured to evaluate associations with adiponectin. Comparison of these variables was performed between the obese and the nonobese group. RESULTS: We found a adiponectin to be significant lower and sICAM-1 significant higher in the obese group compared to the nonobese group, but there were no significant differences in P-selectin and soluble CD40L. Adiponectin was negatively associated with ICAM-1 and P-selectin in the obese group. CONCLUSION: Negative associations of adiponectin with ICAM-1 and P-selectin in obese children and adolescents suggest that serum adiponectin level may represent the inflammatory status.
