Relationship Between Serum Magnesium and Parathyroid Hormone Levels in Hemodialysis Patients.
- Author:
Seong Kwon MA
1
;
Jeong Ki KIM
;
Mi Jung PARK
;
Byoung Seok PARK
;
Myong Yun NAH
;
Chung Ho YEUM
;
Soo Wan KIM
;
Nam Ho KIM
;
Young Joon KANG
;
Ki Chul CHOI
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea. choikc@chonnam.chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Magnesium;
Parathyroid hormone (PTH);
Renal osteodystrophy;
Calcium sensing receptor
- MeSH:
Alkaline Phosphatase;
Aluminum Hydroxide;
Calcium;
Calcium Carbonate;
Humans;
Magnesium*;
Parathyroid Hormone*;
Phosphorus;
Receptors, Calcium-Sensing;
Renal Dialysis*;
Renal Osteodystrophy;
Vitamin D
- From:Korean Journal of Nephrology
2000;19(6):1071-1077
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The important factors involved in the regulation of PTH are calcium, vitamin D, and phosphorus. However, recent studies have suggested that magnesium may also play a significant role in the modulation of PTH. The aims of this study was to analyze the relationship between serum magnesium and PTH levels in the hemodialysis patients. We studied 66 stable patients under maintenance hemodialysis for more than 6 months. Calcium carbonate was used as a phosphate binder in all patients. No patient had been previously treated with vitamin D and aluminum hydroxide. Biochemical parameters were evaluated 3 times during 7 months, and the mean values were computed. The mean serum magnesium level was 2.7+/-0.4 mEq/L. Hypermagnesemia(defined as serum Mg>2.2 mEq/L) was found in 60 patients(90.1%). Serum magnesium levels were inversely correlated with serum iPTH levels(r=-0.579; p<0.001). Serum total and ionized calcium levels were inversely correlated with serum iPTH levels(r=-0.743; p<0.001, r=-0.699; p<0.001, respectively). Serum alkaline phosphatase levels positively correlated with serum iPTH levels (r=0.364; p=0.003). In lower iPTH group(serum iPTH
