Relationship Between Serum Vitamin D Levels and Symptoms of Depression in Stroke Patients.
10.5535/arm.2016.40.1.120
- Author:
Sang Hyun KIM
1
;
Hyun SEOK
;
Dong Suk KIM
Author Information
1. Department of Physical Medicine and Rehabilitation, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. nickel0050@gmail.com
- Publication Type:Original Article
- Keywords:
25-hydroxyvitamin D (25-OHD);
Stroke;
Depression
- MeSH:
Depression*;
Humans;
Stroke*;
Vitamin D Deficiency;
Vitamin D*;
Vitamins*
- From:Annals of Rehabilitation Medicine
2016;40(1):120-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate the correlation between depressive symptoms and serum vitamin D levels in stroke patients. METHODS: In total, 126 stroke patients were analyzed. The 25-hydroxyvitamin D (25-OHD) concentration of each patient was used to determine their vitamin D status. Depressive symptoms were assessed using the Beck Depression Inventory II (BDI-II) and the Patient Health Questionnaire 9 (PHQ-9). Functional status was evaluated with the Korean version of the Modified Barthel Index (K-MBI). We compared the clinical questionnaires of a vitamin D-deficient group and a normal group, and evaluated the correlations between BDI-II, PHQ-9, K-MBI, and serum 25-OHD levels. RESULTS: In the vitamin D-deficient group, BDI-II (16.0±12.1) and PHQ-9 (7.4±4.2) scores were significantly higher than those of the normal group (BDI-II, 9.1±7.2; PHQ-9, 4.2±2.9; p<0.01). In a Spearman correlation analysis, a significant negative correlation was found between serum 25-OHD levels and BDI-II (Spearman r=0.177, p=0.048), but there were no significant correlations between serum 25-OHD levels and PHQ-9 or K-MBI. CONCLUSION: Vitamin D deficiency was correlated with the symptoms of depression in stroke patients.
