The utility of the human papillomavirus DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia.
10.3802/jgo.2009.20.4.232
- Author:
Kyeong A SO
1
;
Jin Hwa HONG
;
Jong Ha HWANG
;
Seung Hun SONG
;
Jae Kwan LEE
;
Nak Woo LEE
;
Kyu Wan LEE
Author Information
1. Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea. joyfulplace@hanmail.net
- Publication Type:Original Article
- Keywords:
Vaginal intraepithelial neoplasia;
Human papillomavirus;
Viral load
- MeSH:
Biopsy;
DNA;
Female;
Follow-Up Studies;
Human Papillomavirus DNA Tests;
Humans;
Medical Records;
Prognosis;
Retrospective Studies;
Viral Load
- From:Journal of Gynecologic Oncology
2009;20(4):232-237
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We evaluated the human papillomavirus (HPV) DNA load for the diagnosis and prediction of persistent vaginal intraepithelial neoplasia (VAIN). METHODS: A retrospective review of the medical records of patients with a pathological diagnosis of VAIN was performed. Eligible women (N=48) were followed for cytology and HPV DNA test, and colposcopic biopsies were taken at 3- to 6-month intervals. Thirty-seven patients were followed for more than 6 months; their HPV DNA test results were compared to the cytology results for the prediction of disease prognosis. RESULTS: The degree of VAIN was more severe in patients with a high initial HPV DNA load (p=0.009). Patients with VAIN 2 and VAIN 3 were older than those with VAIN 1 (p=0.005 and 0.008, respectively). In 26 out of 37 patients (70.3%), the VAIN resolved. The other patients had persistent lesions with no progression to invasive vaginal carcinoma. The last follow-up HPV DNA load was significantly higher in the group with persistent VAIN compared to the group with resolved VAIN (p<0.0001). Negative cytology was observed in 25 out of 26 patients in the VAIN resolved group and in nine out of 11 patients in the VAIN persistent group (p=0.205). CONCLUSION: These results suggest that the HPV DNA test, especially for viral load, was more effective for the diagnosis and prediction of persistent VAIN than cytology.
