Efficacy and Tolerability of Anticholinergics in Korean Children with Overactive Bladder: A Multicenter Retrospective Study.
10.3346/jkms.2014.29.11.1550
- Author:
Se Jin PARK
1
;
Ki Soo PAI
;
Jun Mo KIM
;
Kwanjin PARK
;
Kun Suk KIM
;
Sang Hoon SONG
;
Sungchan PARK
;
Sun Ouck KIM
;
Dong Soo RYU
;
Minki BAEK
;
Sang Don LEE
;
Jung Won LEE
;
Young Jae IM
;
Sang Won HAN
;
Jae Min CHUNG
;
Min Hyun CHO
;
Tae Sun HA
;
Won Yeol CHO
;
Hong Jin SUH
Author Information
1. Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Original Article ; Multicenter Study
- Keywords:
Overactive Urinary Bladder;
Urinary Incontinence;
Anticholinergics;
Efficacy;
Tolerability
- MeSH:
Child;
Child, Preschool;
Cholinergic Antagonists/adverse effects/*therapeutic use;
Constipation/etiology;
Dizziness/etiology;
Female;
Humans;
Male;
Retrospective Studies;
Treatment Outcome;
Urinary Bladder, Overactive/*drug therapy
- From:Journal of Korean Medical Science
2014;29(11):1550-1554
- CountryRepublic of Korea
- Language:English
-
Abstract:
We investigated the efficacy and tolerability of various anticholinergics in Korean children with non-neurogenic overactive bladder (OAB). A total of 326 children (males:females= 157:169) aged under 18 yr (mean age 7.3+/-2.6 yr) who were diagnosed with OAB from 2008 to 2011 were retrospectively reviewed. The mean duration of OAB symptoms before anticholinergic treatment was 16.9+/-19.0 months. The mean duration of medication was 5.6+/-7.3 months. Urgency urinary incontinence episodes per week decreased from 1.9+/-3.1 to 0.4+/-1.5 times (P<0.001). The median voiding frequency during daytime was decreased from 9.2+/-5.4 to 6.3+/-4.2 times (P<0.001). According to 3-day voiding diaries, the maximum and average bladder capacity were increased from 145.5+/-66.9 to 196.8+/-80.3 mL and from 80.8+/-39.6 to 121.8+/-56.5 mL, respectively (P<0.001). On uroflowmetry, maximum flow rate was increased from 17.6+/-8.4 to 20.5+/-8.2 mL/sec (P<0.001). Adverse effects were reported in 14 (4.3%) children and six children (1.8%) discontinued medication due to adverse effects. Our results indicate that anticholinergics are effective to improve OAB symptoms and tolerability was acceptable without severe complications in children.
