A Phase III, Randomized, Double-Blind, Matched-Pairs, Active-Controlled Clinical Trial and Preclinical Animal Study to Compare the Durability, Efficacy and Safety between Polynucleotide Filler and Hyaluronic Acid Filler in the Correction of Crow's Feet: A.
10.3346/jkms.2014.29.S3.S201
- Author:
Chang Sik PAK
1
;
Jongho LEE
;
Hobin LEE
;
Jaehoon JEONG
;
Eun Hee KIM
;
Jinwook JEONG
;
Hyeyeon CHOI
;
Byunghwi KIM
;
Sujin OH
;
Iksoo KIM
;
Chan Yeong HEO
Author Information
1. Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seongnam, Korea. lionheo@snu.ac.kr
- Publication Type:Retracted Publication ; Original Article ; Clinical Trial, Phase III ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Polynucleotides;
Polydeoxyribonucleotides;
Rejuvenation;
Wound Healing
- MeSH:
Adult;
Animals;
Dermatologic Surgical Procedures/*methods;
Double-Blind Method;
Elasticity/drug effects;
Female;
Humans;
Hyaluronic Acid/adverse effects/*therapeutic use;
Injections, Intradermal;
Male;
Mice;
Middle Aged;
Polynucleotides/adverse effects/*therapeutic use;
Skin;
Skin Aging;
Surgery, Plastic/*methods;
Treatment Outcome;
Wound Healing
- From:Journal of Korean Medical Science
2014;29(Suppl 3):S201-S209
- CountryRepublic of Korea
- Language:English
-
Abstract:
The Rejuran(R) is a new filler product made from purified polynucleotides. Here we present data from an animal study and a clinical trial to examine the durability, efficacy and safety of the Rejuran(R) on crow's feet. For the animal study, 25 mice were divided into three groups: Group 1 received phosphate buffered saline (PBS); Group 2 were treated with Yvoire(R); and Group 3 were treated with Rejuran(R). The durability and efficacy of each treatment were assessed by microscopy and staining. In the clinical trial, 72 patients were randomized to receive Rejuran(R) treatment for crow's feet on one side and Yvoire-Hydro(R) on the contralateral side, at a ratio of 1:1. Repeated treatments were performed every two weeks for a total of three times, over a total of 12 weeks' observation. All injections and observations of efficacy and safety were performed by the same two investigators. In the animal study, the Rejuran(R) group showed similar durability and inflammatory response to the Yvoire(R) group. Upon efficacy assessment, the Rejuran(R) group showed the greatest elasticity and collagen composition, and a significant difference in skin surface roughness and wrinkle depth. In the clinical trial, the primary and secondary objective efficacy outcome measure showed no statistical significance between the two groups, and in safety outcomes there were no unexpected adverse effects. Our data suggest that the Rejuran(R), as a new regenerative filler, can be useful to reduce wrinkles, by showing evidence for its efficacy and safety.
