Proportion of Multidrug-Resistant Tuberculosis in Human Immunodeficiency Virus/Mycobacterium tuberculosis Co-Infected Patients in Korea.
10.3346/jkms.2012.27.10.1143
- Author:
Joon Sung JOH
1
;
H Christian HONG
;
In A JEONG
;
Bum Sik CHIN
;
Hye Jin YANG
;
Hongjo CHOI
;
Ji Hwan BANG
Author Information
1. Department of Internal Medicine, National Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Tuberculosis;
Multidrug-Resistant Tuberculosis;
HIV
- MeSH:
Adult;
Aged;
Coinfection;
Female;
HIV Infections/*complications/*epidemiology/microbiology;
Humans;
Immunosuppression;
Male;
Middle Aged;
Mycobacterium tuberculosis/isolation & purification;
Prevalence;
Republic of Korea/epidemiology;
Retrospective Studies;
Risk Factors;
Tuberculosis, Multidrug-Resistant/*complications/*epidemiology/microbiology
- From:Journal of Korean Medical Science
2012;27(10):1143-1146
- CountryRepublic of Korea
- Language:English
-
Abstract:
Much controversy surrounds the issue of whether HIV infection is a risk factor for developing multidrug-resistant tuberculosis (MDR-TB). In this study, we evaluated the prevalence of and risk factors for MDR-TB in HIV-infected patients at the National Medical Center of Korea. We reviewed the medical records of HIV/TB co-infected patients from January 2005 to May 2011; the drug susceptibility profiles were available for 55 patients. Of these, 32.7% had MDR-TB, which was approximately 3.6 times higher than the prevalence among the general population. Additionally, there were more additional AIDS-defining clinical illnesses in the MDR-TB group than in the non-MDR-TB group (27.8% vs 5.4%, P = 0.032). These results suggest that HIV infection and HIV-related immunosuppresion may contribute to the development of MDR-TB.
