Serum Pro-hepcidin Could Reflect Disease Activity in Patients with Rheumatoid Arthritis.
10.3346/jkms.2010.25.3.348
- Author:
Hae Rim KIM
1
;
Kyoung Woon KIM
;
So Young YOON
;
Sang Hyon KIM
;
Sang Heon LEE
Author Information
1. Division of Rheumatology, Medical Immunology Center, Konkuk University School of Medicine, Seoul, Korea. shlee@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
Arthritis, Rheumatoid;
Anemia;
Hepcidin;
Prohepcidin
- MeSH:
Adult;
Aged;
Anemia/*blood;
Anti-Bacterial Agents/blood;
Antimicrobial Cationic Peptides/*blood;
Arthritis, Rheumatoid/*blood/immunology/*physiopathology;
Biological Markers/blood;
Female;
Humans;
Interleukin-1beta/blood/immunology;
Interleukin-6/blood/immunology;
Male;
Middle Aged;
Protein Precursors/*blood;
*Severity of Illness Index;
Tumor Necrosis Factor-alpha/blood/immunology
- From:Journal of Korean Medical Science
2010;25(3):348-352
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to analyze the relationship between serum pro-hepcidin concentration and the anemia profiles of rheumatoid arthritis (RA) and to estimate the pro-hepcidin could reflect the disease activity of RA. RA disease activities were measured using Disease Activity Score 28 (DAS28), tender/swollen joint counts, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Anemia profiles such as hemoglobin, iron, total iron binding capacity (TIBC), ferritin, and transferrin levels were measured. Serum concentration of pro-hepcidin, the prohormone of hepcidin, was measured using enzyme-linked immunosorbent assay (ELISA). Mean concentration of serum pro-hepcidin was 237.6+/-67.9 ng/mL in 40 RA patients. The pro-hepcidin concentration was correlated with rheumatoid factor, CRP, ESR, and DAS28. There was a significant correlation between pro-hepcidin with tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6. The pro-hepcidin concentration was significantly higher in the patients with active RA (DAS28>5.1) than those with inactive to moderate RA (DAS28< or =5.1). However, the pro-hepcidin concentration did not correlate with the anemia profiles except hemoglobin level. There was no difference of pro-hepcidin concentration between the patients with anemia of chronic disease and those without. In conclusion, serum concentration of pro-hepcidin reflects the disease activity, regardless of the anemia states in RA patients, thus it may be another potential marker for disease activity of RA.
