Clinicopathological Characteristics of Mucinous Carcinoma of the Breast in Korea: Comparison with Invasive Ductal Carcinoma-Not Otherwise Specified.
10.3346/jkms.2010.25.3.361
- Author:
Seho PARK
1
;
Jaseung KOO
;
Joo Hee KIM
;
Woo Ick YANG
;
Byeong Woo PARK
;
Kyong Sik LEE
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. bwpark@yuhs.ac
- Publication Type:Original Article
- Keywords:
Korea;
Adenocarcinoma, Mucinous;
Breast;
Prognosis
- MeSH:
Adenocarcinoma, Mucinous/diagnosis/genetics/*pathology;
Adult;
Aged;
Aged, 80 and over;
Breast/pathology;
Breast Neoplasms/classification/diagnosis/genetics/*pathology;
Carcinoma, Ductal/diagnosis/genetics/*pathology;
Disease-Free Survival;
Female;
Genes, erbB-2;
Humans;
Korea;
Lymphatic Metastasis;
Mammography;
Middle Aged;
Prognosis;
Retrospective Studies;
Sensitivity and Specificity;
Survival Rate;
Young Adult
- From:Journal of Korean Medical Science
2010;25(3):361-368
- CountryRepublic of Korea
- Language:English
-
Abstract:
Clinicopathological characteristics and prognostic factors of mucinous carcinoma (MC) were compared with invasive ductal carcinoma-not otherwise specified (IDC-NOS). Clinicopathological characteristics and survivals of 104 MC patients were retrospectively reviewed and compared with those of 3,936 IDC-NOS. The median age at diagnosis was 45 yr in MC and 47 yr in IDC-NOS, respectively. The sensitivity of mammography and sonography for pure MC were 76.5% and 94.7%, respectively. MC showed favorable characteristics including less involvement of lymph node, lower stage, more expression of estrogen receptors, less HER-2 overexpression and differentiated grade, and better 10-yr disease-free survival (DFS) and overall survival (OS) (86.1% and 86.3%, respectively) than IDC-NOS (74.7% and 74.9%, respectively). Ten-year DFS of pure and mixed type was 90.2% and 68.8%, respectively. Nodal status and stage were statistically significant factors for survival. MC in Koreans showed similar features to Western populations except for a younger age of onset than in IDC-NOS. Since only pure MC showed better prognosis than IDC-NOS, it is important to differentiate mixed MC from pure MC. Middle-aged Korean women presenting breast symptoms should be examined carefully and evaluated with an appropriate diagnostic work-up because some patients present radiologically benign-like lesions.
