Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis.
10.3347/kjp.2017.55.6.587
- Author:
José Luis MUÑOZ-CARRILLO
1
;
José Luis MUÑOZ-LÓPEZ
;
José Jesús MUÑOZ-ESCOBEDO
;
Claudia MALDONADO-TAPIA
;
Oscar GUTIÉRREZ-CORONADO
;
Juan Francisco CONTRERAS-CORDERO
;
María Alejandra MORENO-GARCÍA
Author Information
1. Laboratory of Cell Biology and Microbiology, Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas, Zacatecas, México. mcbjlmc@mail.com
- Publication Type:Review
- Keywords:
Trichinella spiralis;
trichinellosis;
inflammatory response;
Th1 cytokine;
resiniferatoxin
- MeSH:
Cytokines;
Drug Therapy;
Eosinophils;
Glucocorticoids;
Immune System;
Inflammation*;
Interleukin-12;
Parasites;
Pathology;
T-Lymphocytes;
Therapeutic Uses*;
Trichinella spiralis;
Trichinellosis*
- From:The Korean Journal of Parasitology
2017;55(6):587-599
- CountryRepublic of Korea
- Language:English
-
Abstract:
The immune response against Trichinella spiralis at the intestinal level depends on the CD4⁺ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. However, its therapeutic use is limited, since studies have shown that treatment with GC suppresses the host immune system, favoring T. spiralis infection. In the search for novel pharmacological strategies that inhibit the Th1 immune response (proinflammatory) and assist the host against T. spiralis infection, recent studies showed that resiniferatoxin (RTX) had anti-inflammatory activity, which decreased the serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE₂, as well the number of eosinophils in the blood, associated with decreased intestinal pathology and muscle parasite burden. These researches demonstrate that RTX is capable to inhibit the production of Th1 cytokines, contributing to the defense against T. spiralis infection, which places it as a new potential drug modulator of the immune response.
