Comparison of Ga-67, Tl-201 and Tc-99m MIBI Imaging in Lymphoma Patients.
10.12701/yujm.2002.19.2.107
- Author:
Kyung Ah CHUN
;
Ihn Ho CHO
;
Kyu Chang WON
;
Kyung Hee LEE
;
Hyung Woo LEE
;
Myung Soo HYUN
;
Jae Tae LEE
;
Kyu Bo LEE
- Publication Type:Original Article
- Keywords:
Tc-99m MIBI;
Tl-201;
Ga-67;
Lymphoma
- MeSH:
Biopsy;
Drug Therapy;
Female;
Hodgkin Disease;
Humans;
Lymphoma*;
Lymphoma, Non-Hodgkin;
Radionuclide Imaging;
Tomography, Emission-Computed, Single-Photon
- From:Yeungnam University Journal of Medicine
2002;19(2):107-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. MATERIALS AND METHODS: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. RESULTS: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. CONCLUSION: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.
