Emergence and Spread of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae.
10.14192/kjnic.2015.20.1.7
- Author:
Wonkeun SONG
1
;
Seok Hoon JEONG
;
Jacob LEE
;
Seung Soon LEE
;
Kyungwon LEE
Author Information
1. Department of Laboratory Medicine, Hallym University College of Medicine, Seoul, Korea. swonkeun@hallym.or.kr
- Publication Type:Review
- Keywords:
Class D carbapenemase;
Enterobacteriaceae;
OXA-48-like
- MeSH:
Carbapenems;
Cephalosporins;
Enterobacteriaceae*;
India;
Korea;
Mass Screening;
Middle East;
Penicillins;
Shewanella;
Turkey
- From:Korean Journal of Nosocomial Infection Control
2015;20(1):7-18
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Since 2001, ten more OXA-48 variants have been identified. Shewanella spp. has been thought to be the original host for OXA-48-like enzymes. These enzymes strongly hydrolyze penicillins and weakly hydrolyze carbapenems, with very weak activity against broad-spectrum cephalosporins. The OXA-48-like genes are always plasmid-borne and have been located in insertion sequences. OXA-48-like carbapenemases have been identified mainly from Turkey, North African countries, the Middle East, and India. Furthermore, the emergence and outbreak of OXA-48-like producers in Korea have been reported recently. Because some OXA-48-like-producing Enterobacteriaceae isolates do not exhibit resistance to broad-spectrum cephalosporins and only decreased susceptibility to carbapenems, their detection can be difficult. Adequate screening and detection methods are required to prevent and control the dissemination of OXA-48-like-producing Enterobacteriaceae.
