Deep Venous Thrombosis in the Lower Extremity: Catheter-Directed Thrombolysis.
10.3348/jkrs.2000.43.3.291
- Author:
Byung Suk ROH
1
;
Byung Jun SO
;
En A KIM
;
Ki Han PARK
;
Kwon Ha YOON
;
Seon Kwan JUHNG
;
Jin Jong WON
Author Information
1. Department of Radiology, Wonkwang University School of Medicine, Korea. bsroh@wmc.wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Thrombosis, venous;
Thrombolysis;
Veins, stenosis or obstruction;
Veins, interventional procedures
- MeSH:
Angioplasty;
Constriction, Pathologic;
Female;
Follow-Up Studies;
Hemorrhage;
Humans;
Lower Extremity*;
Male;
Popliteal Vein;
Pulmonary Embolism;
Stents;
Thrombolytic Therapy;
Ultrasonography;
Urokinase-Type Plasminogen Activator;
Venous Thrombosis*;
Warfarin
- From:Journal of the Korean Radiological Society
2000;43(3):291-297
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the efficacy of catheter-directed thrombolysis in treating symptomatic deep venous thrombosis (DVT) in lower limbs. MATERIALS AND METHODS: Twenty-six consecutive patients (16 male and 10 female; mean age, 55 years) with lower extremity DVT underwent thrombolytic therapy. The duration of symptoms was 1 -90 (mean, 17) days: 20 days or less in 16 cases (acute DVT) and less than 20 days in ten (chronic DVT). Catheter-directed infusions of urokinase were administered via ipsilateral popliteal veins, and angioplasty or stent placement was performed after the thrombolytic procedure. Oral medication of warfarin continued for six months, and for the evaluation of venous patency, follow-up ultrasonography was performed. The total dose of infused urokinase was 1,750,000 -10,000,000 (mean 4, 84,000) IU, and the total procedural time was 25 -115 (mean, 64) hours. RESULTS: Lysis was complete in 16 cases (62%, all acute DVT), partial in five (19%, chronic DVT), and failed in five (19%, chronic DVT). Eight patients with venous stenosis and two with occlusion were treated by means of angioplasty (n=4) or Wallstent placement (n=6). Minor bleeding occurred in six cases and major complications in two (one of pulmonary embolism, and one of multiorgan failure). CONCLUSION: Catheter-directed thrombolysis with urokinase is effective for the treatment of DVT in lower limbs.
