A case of de novo B - cell prolymphocytic leukemia associated with false - positive direct antiglobulin test.
- Author:
Ji Soo KIM
1
;
Cheol Su POO
;
Sung Min NOH
;
Heon Jik LEE
;
Yong Seok YANG
;
Seung Young KIM
;
Byeung Yub PARK
Author Information
1. Department of Internal Medicine, Hae Dong Hospital, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Leukemia;
Prolymphocytic
- MeSH:
Bone Marrow;
Coombs Test*;
HLA-DR Antigens;
Humans;
Immunoglobulins;
Immunophenotyping;
Leukemia;
Leukemia, Prolymphocytic*;
Leukemia, Prolymphocytic, B-Cell;
Leukocytosis;
Lymphatic Diseases;
Lymphocytosis;
Middle Aged;
Splenomegaly
- From:Korean Journal of Medicine
2000;59(4):428-432
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
De novo B-cell prolymphocytic leukemia (B-PLL) is a distinct clinicopathologic entity that was first described in 1974 by Galton et al. B-PLL is characterized by marked lymphocytosis with predominance of prolymphocytes, often massive splenomegaly, minimal lymphadenopathy, often aggressive clinical course and frequently poor prognosis.We experienced a case of B-PLL associated with false-positive direct antiglobulin test. The patient was 52 year-old man who presented with marked leukocytosis (160.2x103/(mu)L) and 60% of characteristic prolymphocytes in the peripheral blood. The bone marrow aspirate showed dry tap and the PAS stain of peripheral blood smear showed positivity of prolymphocytes. The immunophenotyping of the leukemic prolymphocytes revealed the positivity of surface immunoglobulin (IgM, lambda type), HLA-DR, CD19 and CD5.
