5-Fluorouracil in a Collagen Sponge and Glaucoma Filtering Surgery.
- Author:
Dong Myung KIM
1
Author Information
1. Depatrment of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- MeSH:
Antineoplastic Agents;
Blister;
Collagen*;
Drug-Related Side Effects and Adverse Reactions;
Fibroblasts;
Filtering Surgery*;
Fluorouracil*;
Glaucoma*;
Longevity;
Porifera*;
Rabbits
- From:Journal of the Korean Ophthalmological Society
1988;29(5):901-907
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A histologic study was performed if fibroblast proliferation could be inhibited and filtering bleb longevity could be enhanced in rabbits by delivery of 5-fluorouracil(0.5 mg) in a collagen sponge implant. Results showed that fibroblast proliferation was inhibited and bleb longevity was prolonged when compared to controls. And it is theorized that if an antitumor agents can be delivered in small and sustained amounts after filtering agents can be delivered in small and sustained amounts after filtering surgery, this may enhance bleb longevity and unnecessary drug toxicity.
