Hypotensive Effect of 2% Mikelan(R) and 1% Bentos(R) and Combined Therapy of 2% Mikelan(R), 1% Bentos(R) in Normal Volunteers.
- Author:
Sung Gyun SHIN
1
;
Sae Heun RHO
Author Information
1. Department of Ophthalmology, School of Medicine, Pusan Paik Hospital, Inje College, Pusan, Korea.
- Publication Type:Original Article
- MeSH:
Blood Pressure;
Healthy Volunteers*;
Heart Rate;
Masks;
Pupil;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
1988;29(5):915-919
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thirty normal volunteers(60 eyes) of the third decade were evaluated. Thirty normal volunteers were divided into three groups, -2% Mikelan group, 1% Bentos group and combined group of 2% Mikelan and 1% Bentos-. Double masked single dose study was done by instillation each eye solution into the one eye selected randomly. The intraoculat pressure, pupil size, visual acuity, blood pressure and pulse rate were measured before the instillation of eye solution and 30 minutes, 1, 2, 3, 4, 5, 6 hours after instillation and the statistical significance was estimated using the paired t-test. The following results were obtained: 1. In group of 2% Mikelan(R), the IP reduction was noted since thirty minutes after instillation and maximum reduction ratio of IOP was 45.5% at 4 hours after instillation than IOP measured before instillation. 2. In both groups of 1% Bentos(R) and combined group of 2% Mikelan(R) and 1% Bentos(R), the IOP reduction was noted since 1 hour after instillation and each maximum reduction ratio of IOP was 32.8%, 34.9% at 4 hours after instillation than IOP measured before instillation. 3. Statistically significant IOP reduction was also noted in the contralateral eyes in each group. 4. Statistically significant IOP reduction was noted in 2% Mikelan(R) group than 1% Bentos(R) group on 30 minutes, 1, 2, 4, 6 hours after instillation. 5. Statistically significant IOP reduction was noted in 2% Mikelan(R) group than combined group of 2% Mikelan(R) and 1% Bentos(R) on 30 minutes, 1, 4, 6 hours after instillation. 6. Synergistic effect of IOP reduction in combined therpy of 2% Mikelan(R) and 1% Bentos(R) was not noted. 7. The pupil size, visual acuity, blood pressure and pulse rate were not changed significantly after the instillation of 2% Mikelan(R), 1% Bentos(R).
