Effect of Hormone Replacement Therapy on Dry Eye Syndrome in Postmenopausal Women: A Prospective Study.
10.3341/jkos.2010.51.2.175
- Author:
Jung Hyun MOON
1
;
Jee Woong JUNG
;
Kyung Hwan SHIN
;
Hye Jung PAIK
Author Information
1. Department of Ophthalmology, Gachon University Gil Medical Center, Incheon, Korea. hjpaik@gilhospital.com
- Publication Type:Original Article
- Keywords:
Dry eye syndrome;
Hormone replacement therapy;
Postmenopausal woman
- MeSH:
Dry Eye Syndromes;
Estrogens;
Female;
Fluorescein;
Hormone Replacement Therapy;
Humans;
Progesterone;
Prospective Studies;
Tears
- From:Journal of the Korean Ophthalmological Society
2010;51(2):175-179
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effects of conjugated hormone replacement therapy (HRT) on dry eye syndrome in postmenopausal women. METHODS: Thirty-six healthy postmenopausal women (72 eyes) were included in this three-month prospective study. Schirmer test, tear film break-up time (BUT), fluorescein staining score and symptom score were performed on all patients at the time of enrollment, one month and three months after initiation of HRT. All patients received HRT consisting of conjugated estrogen and progesterone taken orally in a continuous combined regimen. RESULTS: Symptom score significantly decreased from 2.10+/-0.79 before HRT to 1.32+/-0.84 after one month and to 0.88+/-0.67 after three months (p<0.001). In addition, tear film BUT measurements significantly increased from 6.04+/-2.54 seconds to 7.99+/-2.43 seconds after one month and to 8.93+/-2.20 after three months (p<0.001). The fluorescein staining score was 0.94+/-0.71 before HRT and decreased to 0.42+/-0.60 after one month and to 0.22+/-0.42 after three months (p<0.001). CONCLUSIONS: Hormone replacement therapy consisting of conjugated estrogen and progesterone significantly improved the symptoms and signs of dry eye syndrome in postmenopausal women.
