Association between Cerebral Amyloid Deposition and Clinical Factors Including Cognitive Function in Geriatric Depression: Pilot Study Using Amyloid Positron Emission Tomography.
10.9758/cpn.2016.14.4.378
- Author:
Hye Geum KIM
1
;
Eun Jung KONG
;
Eun Jin CHEON
;
Hae Won KIM
;
Bon Hoon KOO
Author Information
1. Department of Psychiatry, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Korea. vijnana@chol.com
- Publication Type:Original Article
- Keywords:
Amyloid positron emission tomography;
Geriatric depression;
Alzheimer disease;
Subjective memory complaint
- MeSH:
Alzheimer Disease;
Amyloid*;
Attention;
Brain;
Cognition*;
Depression*;
Depressive Disorder, Major;
Electrons*;
Memory;
Memory, Short-Term;
Pilot Projects*;
Plaque, Amyloid*;
Positron-Emission Tomography*
- From:Clinical Psychopharmacology and Neuroscience
2016;14(4):378-382
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study was to explore the relationship between cerebral amyloid deposition and overall clinical factors including cognitive functions in geriatric depression by using 18F-florbetaben positron emission tomography. Thirteen subjects aged over 60 years who had a history of major depressive disorder and also had subjective memory complaint were included. Of all subjects, 3 subjects judged as amyloid positive, and the others judged as amyloid negative. Their memory, visuospatial functions and attention abilities were negatively correlated with amyloid deposition in specific brain regions, but their language and recognition abilities were not correlated with any region. The amyloid deposition of the whole brain region was significantly negatively correlated with immediate memory.
