Serotonin Syndrome after Clomipramine Overdose in a Child.
10.9758/cpn.2016.14.4.388
- Author:
Meltem Cobanoğulları DIREK
1
;
Veli YILDIRIM
;
Serkan GÜNEŞ
;
Gülçin BOZLU
;
Cetin OKUYAZ
Author Information
1. Division of Pediatric Neurology, Department of Pediatrics, University of Mersin School of Medicine, Mersin, Turkey. m_lt_m82@hotmail.com
- Publication Type:Case Report
- Keywords:
Child;
Clomipramine;
Serotonin syndrome;
Risperidone;
Early diagnosis
- MeSH:
Central Nervous System;
Child*;
Clomipramine*;
Consciousness;
Critical Care;
Dihydroergotamine;
Early Diagnosis;
Emergency Medicine;
Emergency Service, Hospital;
Extremities;
Female;
Fever;
Humans;
Physical Examination;
Pupil;
Reflex, Stretch;
Risperidone;
Serotonin Agents;
Serotonin Syndrome*;
Serotonin*;
Skin;
Specialization;
Tremor
- From:Clinical Psychopharmacology and Neuroscience
2016;14(4):388-390
- CountryRepublic of Korea
- Language:English
-
Abstract:
Serotonin syndrome (SS) is a potentially life-threatening condition associated with increased serotonergic activity in central nervous system and may occur during the use of serotonergic drugs. Although increasing frequency of serotonergic drug use in children, pediatricians, emergency medicine and pediatric intensive care specialists have not enough knowledge and experience about SS that is a potentially life-threatening condition. A 12-year-old girl patient was admitted to our emergency room with the history of involuntary contractions on her extremities and alteration of consciousness. Her physical examination showed agitation, hyperthermia, dilated pupils, tremor, increased deep tendon reflexes, positive spontaneous clonus, agitation, flushed skin and diaphoresis, excessive perspiration, and continuous horizontal ocular movements. The patient diagnosed as SS by clinical history, physical and laboratory findings. In this paper, we will discuss SS occurred in a 12-year-old girl after concurrent clomipramine and risperidone use.
