Efficacy of Percutaneous Cholangioscopic Ethanol Injection in Hepatocellular Carcinoma Invading the Bile Duct.
- Author:
Jung Min CHOI
1
;
Sung Koo LEE
;
Sang Soo LEE
;
Jang Han LEE
;
Moon Hee SONG
;
Dae Keun PYUN
;
Tae Jun SONG
;
Jung Sik CHOI
;
Do Hyun PARK
;
Dong Wan SEO
;
Myung Hwan KIM
;
Young Il MIN
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sklee@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Hepatocellular carcinoma;
Bile duct invasion;
Percutaneous cholangioscopic ethanol injection;
Percutaneous transhepatic biliary drainage
- MeSH:
Bile Ducts*;
Bile*;
Carcinoma, Hepatocellular*;
Cholangitis;
Constriction, Pathologic;
Drainage;
Ethanol*;
Hemobilia;
Hemorrhage;
Humans;
Liver Failure;
Retrospective Studies;
Rupture;
Sepsis
- From:Korean Journal of Gastrointestinal Endoscopy
2005;30(6):305-311
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: To evaluate the clinical outcomes of the percutaneous cholangioscopic ethanol injection in the hepatocellular carcinoma (HCC) invading the bile duct, we conducted a retrospective study. METHODS: Ten patients who received the percutaneous cholangioscopic ethanol injection were selected patients were diagnosed as HCC invading the bile duct between January 1998 and February 2004. Treatment response, complications, survival or death and survival time were analyzed. RESULTS: Ten patients received mean of 5.3 sessions (range 2~19) of cholangioscopic ethanol injection. Eight patients had decreased tumor mass, and the rest 2 patients had no response. Complications were pain (n=10), hemobilia (n=6: bleeding was minimal), cholangitis (n=2), bile duct rupture (n=1), and bile duct stricture (n=1). Nine patients died from severe hepatic failure and sepsis, one patient has survived for 19 months as of now. Median survival time was 5 months (range 2~19 months). Percutaneous transhepatic biliary drainage (PTBD) could be removed in two patients. CONCLUSIONS: Percutaneous cholangioscopic ethanol injection in HCC invading the bile duct showed size reduction of mass. PTBD could be no longer needed in some patients. However, supportive cares such as PTBD may be appropriate considering their short survival period and risk of procedure.
