Epstein-Barr Virus Associated Lymphoepithelial Carcinoma of the Parotid Gland: A case report.
- Author:
Kwang Il KIM
;
Young Sik KIM
;
In Sun KIM
- Publication Type:Case Report
- Keywords:
Lymphoepithelial carcinoma;
Salivary gland;
Epstein-Barr virus
- MeSH:
Carcinoma;
Herpesvirus 4, Human*;
Humans;
In Situ Hybridization;
Incidence;
Islands;
Middle Aged;
Parotid Gland*;
Polymerase Chain Reaction;
Salivary Glands
- From:Korean Journal of Pathology
1998;32(2):150-152
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lymphoepithelial carcinoma is a rare subtype of undifferentiated carcinoma in the salivary gland. The incidence of lymphoepithelial carcinoma is about 0.4% among the patients with major salivary gland tumors. It has a racial preference; about 75% of the patients are of Mongolian ancestry. We report a case of lymphoepithelial carcinoma arising in the left parotid gland of a 52-year-old man. Grossly, the tumor was relatively well demarcated, gray-white, and solid. Microscopically, the irregular shaped syncytial tumor cell islands were evident within lymphoplasma cell-rich and desmoplastic stroma. The carcinoma cells had large vesicular nuclei and prominent nucleoli. The tumor invaded the surrounding salivary gland tissue. Epstein-Barr virus (EBV) was demonstrated by in situ hybridization for EBV-encoded RNA-1 (EBER-1) and polymerase chain reaction for EBV nuclear antigen-1 (EBNA-1).
