A Study of Factor XII Deficiency in Recurrent Spontaneous Abortion.
- Author:
Yoon Sung NAM
;
Nam Keun KIM
;
Su Man LEE
;
Myung Seo KANG
;
Doyeon OH
;
Kwang Yul CHA
- Publication Type:Original Article
- Keywords:
Factor XII deficiency;
aPTT;
Recurrent spontaneous abortion
- MeSH:
Abortion, Spontaneous*;
Factor XII Deficiency*;
Factor XII*;
Female;
Humans;
Pregnancy
- From:Korean Journal of Fertility and Sterility
2001;28(3):209-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate factor XII deficiency in patients with recurrent spontaneous abortion and its relation to aPTT. MATERIAL AND METHOD: Factor XII was analyzed by clotting method. RESULTS: Of 70 patients with recurrent spontaneous abortion, there were 35 cases of factor XII deficiency. Among them, there were only 3 cases of prolonged aPTT. CONCLUSIONS: It is still unclear whether factor XII deficiency is related to recurrent spontaneous abortion. Molecular approaches should be used to understand further the causal relationship. But based on this result, in the workup of patients with recurrent spontaneous abortion, factor XII should be included. aPTT is not likely to represent the abnormality of factor XII.
