The Analysis of Methylenetetrahydrofolate Reductase Mutation in Recurrent Spontaneous Abortion.
- Author:
Yoon Sung NAM
;
Kwang Yul CHA
;
Nam Keun KIM
;
Sun Hee KIM
;
Jin Woo LIM
;
Geum Duk KANG
;
Myung Seo KANG
;
Se Hyun KIM
;
Doyeun OH
- Publication Type:Original Article
- Keywords:
Recurrent spontaneous abortion;
MTHFR mutation
- MeSH:
Abortion, Spontaneous*;
Female;
Humans;
Hyperhomocysteinemia;
Methylenetetrahydrofolate Reductase (NADPH2)*;
Pregnancy
- From:Korean Journal of Fertility and Sterility
2001;28(3):247-
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To analyze the methylenetetrahydrofolate reductase (MTHFR) mutation in patients with recurrent spontaneous abortion. MATERIAL AND METHOD: The blood samples of patients with recurrent spontaneous abortion were tested by PCR-RFLP method. RESULTS: Of 51 cases of study group, 14 (27.5%) were normal, 25 (49.0%) were heterozygosity, and 12 (23.5%) were homozygosity. Of 58 cases of control group, 20 (34.5%) were normal, 30 (51.7%) were heterozygosity, and 8 (13.8%) were homozygosity. But the difference between two groups was not significant (p=0.190). CONCLUSION: Hyperhomocysteinemia due to MTHFR mutation is a cause of recurrent spontaneous abortion. Therefore, the study for MTHFR mutation should be included in the workup of recurrent spontaneous abortion.
