A case of Human Herpesvirus 8 Related Kaposi's Sarcoma in a Patient with Iatrogenic Cushing's Syndrome.
- Author:
Nyoung Hoon YOUN
1
;
Dong O YOU
;
Seok Don PARK
;
Seung Hoon CHA
Author Information
1. Department of Dermatology, Wonkwang University School of Medicine, Iksan, korea. shcha@wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Kaposi's sarcoma;
Human herpesvirus 8;
Iatrogenic cushing's syndrome
- MeSH:
Adrenal Cortex Hormones;
Aged;
Cushing Syndrome*;
Dermis;
Female;
Forearm;
Herpesvirus 8, Human*;
Humans*;
Leg;
Low Back Pain;
Purpura;
Sarcoma, Kaposi*;
Skin
- From:Korean Journal of Dermatology
2001;39(9):985-990
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Kaposi's sarcoma(KS) is a multicentric proliferative vascular tumor involving cutaneous and visceral tissues. KS was one of the first recognized manifestations of AIDS. A 71-year-old woman was seen with multiple violaceous nodules and painful erythematous cellulitis-like swelling on both lower legs. Easy bruising and senile purpura was also noted on her forearms. She had been suffered from lower back pain for 7 years, and had been treated with corticosteroids. Clinical picture and hormonal study revealed that she had iatrogenic Cushing's syndrome. The histopathologic study from skin lesion showed abnormally proliferated and dilated vessels, vascular slits, spindle shaped cells in the entire dermis. Human herpesvirus 8(HHV-8) was detected by nested polymerase chain reaction(PCR) using the paraffin-embedded skin tissue. She received localized radiotherapy(50 Gray) to both lower legs with favorable response. But five months later, her skin lesions had recurred and progressed into more aggressive pattern mainly on her left lower leg. We report a rare case of human herpesvirus 8 related KS in iatrogenic Cushing's syndrome.
