Two Cases of Intravitreal Ganciclovir Injection for Cytomegalovirus Retinitis.
10.3341/jkos.2013.54.6.977
- Author:
Jung Bin HAN
1
;
Seung Won LEE
;
Hyung Woo KWAK
Author Information
1. Department of Ophthalmology, KyungHee University Medical Center, KyungHee University School of Medicine, Seoul, Korea. hwkwak@khu.ac.kr
- Publication Type:Case Report
- Keywords:
Cytomegalovirus retinitis;
Ganciclovir;
Intravitreal ganciclovir injection
- MeSH:
Antibodies, Monoclonal, Humanized;
Cytomegalovirus;
Cytomegalovirus Retinitis;
Eye;
Female;
Follow-Up Studies;
Ganciclovir;
Heart Failure;
Humans;
Immunoglobulin G;
Intravitreal Injections;
Macular Edema;
Male;
Mycophenolic Acid;
Retinal Hemorrhage;
Retinal Vein;
Retinitis;
Serologic Tests;
Subretinal Fluid;
Tacrolimus;
Transplants;
Visual Acuity;
Vitrectomy;
Bevacizumab
- From:Journal of the Korean Ophthalmological Society
2013;54(6):977-981
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report 2 cases of cytomegalovirus retinitis treated with intravitreal ganciclovir. CASE SUMMARY: A 29-year-old female (Case 1) who received immunosuppressive therapy with tacrolimus and mycophenolate mofetil for 3 months after pancreatic transplantation, was given an intravitreal Bevacizumab injection 4 times in each eye under the suspicion of bilateral central retinal vein occlusion. During follow-up, a new lesion with white opacification and multiple snowballs appeared in the left eye. Suspecting cytomegalovirus retinitis, we administered an intravitreal ganciclovir injection resulting in a decrease of white opacification and improvement of visual acuity. A 66-year-old male (Case 2) who was receiving treatment for general weakness and heart failure, presented with visual disturbance in both eyes. Fundoscopic examination revealed white opacification, multiple snowballs and retinal hemorrhage in the left eye; diagnostic vitrectomy was performed. Macular edema and subretinal fluid continued after the vitrectomy and the serologic testing revealed an IgG titer positive for cytomegalovirus, therefore, an intravitreal injection of ganciclovir was given. Macular edema and subretinal fluid decreased and visual acuity improved. CONCLUSIONS: Intravitreal ganciclovir can be an effective treatment option for the management of CMV retinitis.
