Preemptive Analgesic Effect of Magnesium Sulfate on Postoperative Pain after Hysterectomy.
10.4097/kjae.1999.37.3.447
- Author:
Kwnag Jo OH
1
;
Moo Soo HEO
;
Seong Hoon KO
;
Yeong Jin HAN
;
Huhn CHOE
Author Information
1. Department of Anesthesiolgy Chonbuk National University Medical School, Chonju, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Analgesia, preemptive;
Ions, magnesium;
Pain, postoperative
- MeSH:
Humans;
Hydrogen-Ion Concentration;
Hysterectomy*;
Magnesium Sulfate*;
Magnesium*;
N-Methylaspartate;
Pain, Postoperative*
- From:Korean Journal of Anesthesiology
1999;37(3):447-452
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Recent studies suggest that preoperative block of the N-Methyl-D-Aspartate (NMDA) receptor with NMDA antagonists may reduce postoperative pain. We infused magnesium sulfate, anatural NMDA receptor antagonist, preoperatively to evaluate the preemptive analgesic effect of magnesium. METHODS: Sixty healthy patients who underwent total abdominal hysterectomy under general sthesia were randomly divided into three groups. Group 1 was the control group, while Groups 2 and 3 received intravenous magnesium (Group 2 : 0.1 mg/kg bolus, 0.015 mg/kg/hr for 6hr, Group 3 : 0.2 mg/kg bolus, 0.03 mg/kg/hr for 6hr). Postoperative pain scorers (Visual Analog Scale: VAS and Prince Henry Score: PHS) and the amount of analgesic consumption were evaluated at 6, 24, 48 and 72 hours by a double blind manner. RESULTS: The patients in Group 3 had lower pain scores at 6 and 24 hours compared to those in Group 1, but there were no significant differences in PHS and cumulative amounts of analgesic consumption among the three groups. CONCLUSIONS: The preoperative administration of intravenous magnesium reduced postoperative pain scores. However, further study is needed before its clinical use for postoperative analgesic purposes.
