Nonalcoholic fatty liver disease as a risk factor of cardiovascular disease; Relation of non-alcoholic fatty liver disease to carotid atherosclerosis.
10.3350/kjhep.2008.14.1.77
- Author:
Su Yeon CHOI
1
;
Donghee KIM
;
Jin Hwa KANG
;
Min Jung PARK
;
Young Sun KIM
;
Seon Hee LIM
;
Chung Hyeon KIM
;
Hyo Suk LEE
Author Information
1. Seoul National University Hospital Healthcare System Gangnam Center, Healthcare Research Institute, Department of Internal medicine, Seoul National University College of Medicine, Seoul, Korea. messmd@chol.com
- Publication Type:Original Article ; English Abstract
- Keywords:
Fatty liver;
Carotid atherosclerosis;
Metabolic syndrome;
Cardiovascular;
Risk
- MeSH:
Aged;
Body Mass Index;
Carotid Arteries/pathology/ultrasonography;
Carotid Artery Diseases/diagnosis/*etiology;
Cholesterol, HDL/blood;
Demography;
Diabetes Mellitus, Type 2/complications/diagnosis;
Diabetic Diet;
Fatty Liver/*complications/diagnosis/ultrasonography;
Female;
Humans;
Male;
Metabolic Syndrome X/complications/diagnosis;
Middle Aged;
Obesity/complications/diagnosis;
Regression Analysis;
Risk Factors;
Triglycerides/blood
- From:The Korean Journal of Hepatology
2008;14(1):77-88
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) is closely associated with abdominal obesity, dyslipidemia, hypertension, and Type 2 diabetes, which are all features of the metabolic syndrome. The aim of the present study was to elucidate whether NAFLD is associated with carotid atherosclerosis. METHODS: The study population comprised 659 subjects without hepatitis B and C infections and who did not consume alcohol. Fatty infiltrations of liver were detected by abdominal ultrasonography, and intima-media thickness (IMT) and plaque prevalence were estimated by carotid ultrasonography. RESULTS: The mean values of systolic and diastolic pressures, body mass index (BMI), aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, uric acid, total cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, fasting glucose, fasting insulin, homeostasis model of assessment (HOMA) index, hemoglobin A1c, and plasminogen activator inhibitor-1 differed significantly between patients with NAFLD (n=314) and normal controls (n=345). The carotid IMT was 0.817+/-0.212 (mean+/-SD) mm in patients with NAFLD and 0.757+/-0.198 mm in normal controls (p<0.001). The prevalence of carotid plaques was higher in patients with NAFLD (26.4%) than in normal controls (15.9%) (p<0.001). This association persisted significantly after adjusting for age, sex, BMI, HOMA index and individual factors of metabolic syndrome by multiple logistic regression analysis. CONCLUSIONS: Patients with NAFLD are at a high risk of carotid atherosclerosis regardless of metabolic syndrome and classical cardiovascular risk factors. Therefore, the detection of NAFLD should alert to the existence of an increased cardiovascular risk. Moreover, NAFLD might be an independent risk factor for cardiovascular disease.
