Humoral and Cell Mediated Immune Response After Immunization with Varicella Vaccine (Oka/LG).
- Author:
Young Mo SOHN
1
;
Hye Ok ROH
;
Mi Lim GOO
;
Bok Ryeon PARK
;
Joo Hong PARK
;
Gook Jin LIM
Author Information
1. Department of Pediatrics, Yongdong Severance Hospital, Yonsei University, LG Biotech, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Varicella-zoster virus;
Vaccination;
Immune response
- MeSH:
Adult;
Antibodies;
Blotting, Western;
Chickenpox Vaccine*;
Chickenpox*;
Child;
Glycoproteins;
Herpesvirus 3, Human;
Humans;
Immunity, Cellular;
Immunization Schedule;
Immunization*;
Immunoglobulin G;
Korea;
Membranes;
Surveys and Questionnaires;
Seroepidemiologic Studies;
Vaccination;
Vaccines
- From:Journal of the Korean Pediatric Society
1998;41(2):170-178
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the humoral and cellular immune response to varicella-zoster virus after vaccination with varicella vaccine (Oka/LG strain). METHODS: The seroprevalence rate of fluorescent antibody to membrane antigen (FAMA) was evaluated among 178 children and 15 adults. After vaccination, seroconversion rate of FAMA, varicella-zoster virus (VZV) specific IgG and cell mediated immune response to glycoprotein I was performed. RESULTS: The seropositive rate of FAMA against VZV in healthy children ages 3 to 6 was 43.1%. A past history of chickenpox illness was confirmed in 15.2% of children who had positive response in FAMA assay in 90.9%. 34.5% of those without a past history of chickenpox had antibodis. The seropositive rate in children vaccinated with varicella vaccine in the past was found to be 46.3% in questionnaire and 44.4% in immunization schedule, lower than that of other studies (greater than 90%). The seroconversion rates in children vaccinated with the Oka/LG were 97.1% with 2,500pfu and 100.0% with 5,000pfu. Antibodies appearing after the Oka/LG vaccination were found to have glycoprotein I zone confirmed by western blotting. The rate of cell mediated immune response was 88.2% in children and 100.0% in adults. CONCLUSION: Further investigation about the effect of the various varicella vaccines used in Korea and about the cause of their immunzation failure after vaccination is needed.
