Serial Measured Glucose Level and Neurological Outcome in Out of Hospital Cardiac Arrest Survivors Who Received Therapeutic Hypothermia.
- Author:
Jee Yong JANG
1
;
Yong Su LIM
;
Hyuk Jun YANG
;
Won Bin PARK
;
Sung Youl HYUN
;
Jin Sung CHO
;
Jin Joo KIM
;
Mi Jin LEE
Author Information
1. Department of Emergency Medicine, School of Medicine, Gachon University, Incheon, Korea. yongem@gilhospital.com
- Publication Type:Original Article
- Keywords:
Heart arrest;
Cardiopulmonary resuscitation;
Glucose;
Hyperglycemia;
Hypothermia
- MeSH:
Cardiopulmonary Resuscitation;
Dinucleoside Phosphates;
Glucose;
Heart Arrest;
Humans;
Hyperglycemia;
Hypothermia;
Logistic Models;
Out-of-Hospital Cardiac Arrest;
Prognosis;
Retrospective Studies;
Survivors
- From:Journal of the Korean Society of Emergency Medicine
2011;22(2):142-150
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In patients resuscitated from out-of-hospital cardiac arrest (OHCA), the influences of serial serum glucose and variability on neurological outcome are not well understood. We investigated the influence of serum glucose and variability on neurological outcome in OHCA survivors. METHODS: Records of 105 OHCA survivors who received therapeutic hypothermia (TH) between April, 2007 and January, 2010 were retrospectively reviewed. By neurological prognosis at 6 months after restoration of spontaneous circulation, patients were divided to two groups based on cerebral performance category (CPC) score; 1-2 (good) and 3-5 (poor). The serial measured glucose level and glucose variability during 72 hours were compared between the groups. RESULTS: The poor CPC group had statistically higher mean, median and maximum glucose level, but not minimal glucose, compared to the good CPC group. The poor CPC group also comparatively displayed higher standard deviation and time-glucose variability index (TGVI) of glucose level during 72 hours. Multiple logistic regression demonstrated that increased TGVI was significantly associated with poor neurological outcome (odds ratio 1.304, 95% confidence interval 1.078-1.578) CONCLUSION: Serial glucose level and variability are strongly related with neurological outcome in post-resuscitated patients who received TH after OHCA. Further randomized controlled studies are needed.
