Serum Pepsinogen l, ll Levels and Upper Gastrointestinal Diseases in Children with H. pylori Infection.
- Author:
Je Woo KIM
1
;
Ki Sup CHUNG
Author Information
1. Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
H. pylori;
Serum pepsinogen l and ll levels;
Upper gastrointestinal disease
- MeSH:
Age Distribution;
Child*;
Duodenal Ulcer;
Gastritis;
Gastrointestinal Diseases*;
Helicobacter;
Humans;
Pepsinogen A*;
Radioimmunoassay;
Silver
- From:Journal of the Korean Pediatric Society
1998;41(2):200-208
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In H. pylori infection serum pepsinogen l/ll ratio decreases and pepsinogen ll level is increased. Increased serum pepsinogen ll level correlates with pathologic severity of gastritis. We assayed serum pepsinogen l, ll levels and pepsinogen l/ll ratio to evaluate the relationship between the serum pepsinogen level and upper gastrointestinal diseases. METHODS: One hundred and sixty-five children who had undergone upper gastrodudenal endoscopic examination with CLO test and silver stain were included. Pepsinogen l and ll levels were detected in serum by radioimmunoassay. RESULTS: Age distributions were: 3 patients below 5 years, 55 patients between 6 and 10 and 107 over 11. Thirty-two (19%) were H. pylori positive, and 133 (81%) were negative. Pepsinogen l increased in H. pylori positive children (P<0.01). Pepsinogen ll were higher in the H. pylori positive patients compared to Helicobactor negative group (P<0.001). Pepsinogen l and II were significantly higher (P<0.01 in pepsinogene l: P<0.01 in ll) in children with nodular gastritis with Helicobactor positive than any other disease including H. pylori negative without duodenal ulcer. Pepsinogen l/ll ratio was lower in children with nodular gastritis with H. pylori positive (P<0.001) than in children with any other disease including Helicobacter negative. CONCLUSION: These results suggest that serum pepsinogen levels are inportnat in pathogenesis of upper gastrointestinal disease in children with H. pylori infection.
