Age-related Circulating Inflammatory Markers and Cardiovascular Disease Risk Factors in Korean Women.
- Author:
Ho Kyung KWAK
1
;
Mi Joung KIM
Author Information
1. Department of Home Economics, Korea National Open University, 169 Donsung-dong, Chongno-gu, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
aging;
body mass index;
cholesterol;
tumor necrosis factor-alpha;
homocysteine
- MeSH:
Aging;
Apolipoproteins;
Biomarkers;
Body Mass Index;
C-Reactive Protein;
Cardiovascular Diseases;
Cell Adhesion;
Cholesterol;
Female;
Homocysteine;
Humans;
Inflammation;
Nitric Oxide;
Risk Factors;
Thiobarbiturates;
Thiobarbituric Acid Reactive Substances;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Community Nutrition
2009;14(4):451-461
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of this study was to investigate the age-related changes of cardiovascular disease risk factors and inflammatory markers in non-obese Korean women. Subjects were 112 women over 20 years old with body mass index (BMI) less than 30 kg/m2 and were divided into 3 groups (< 40 years, 40~59 years, > or = 60 years). Mean weight and BMI in the oldest group were significantly higher than those in the other 2 younger groups (P <0.05). Mean total cholesterol, triglyceride, LDL-cholesterol and apolipoprotein B/apolipoprotein A1 ratio (BAR) in the oldest group were significantly higher than those in the youngest group (P <0.05), and mean HDL-cholesterol of the oldest group was significantly lower than that of the youngest group (P <0.05). The older-aged group showed significantly higher mean values of atherogenic index (AI) and LDL/HDL ratio (P <0.05) than the respective younger-aged group, and AI was significantly correlated with age, nitric oxide and thiobarbituric acid reactive substances (P <0.01). In addition, mean vascular cell adhesion molecule-l (VCAM-1) tended to be higher in the older-aged group than the younger group. Tumor necrosis factor-alpha, a proinflammatory maker, was significantly positively correlated with serum homocysteine, a cardiovascular disease risk factor (P <0.01). In addition, a significantly positive correlation was observed between C-reactive protein and BAR (P <0.01). Overall results suggested that the aging might affect the increase of cardiovascular disease risk factors including the serum lipid profiles, weight and BMI, and age-related increases of weight and BMI might play a role in changes in certain biomarkers of inflammation.
