Localized Paroxysmal Pruritus in Multiple Sclerosis.
- Author:
Jung Hoan YOO
1
;
Hong Suk KIM
;
Dong Seung KANG
;
Kee Yang CHUNG
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Multiple sclerosis;
Paroxysmal itching;
Ibuprofen
- MeSH:
Adult;
Axons;
Carbamazepine;
Female;
Humans;
Ibuprofen;
Multiple Sclerosis*;
Neck;
Phenytoin;
Pruritus*;
Synapses;
Thorax
- From:Korean Journal of Dermatology
2000;38(3):410-412
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Paroxysmal itching is a rare symptom in multiple sclerosis and it was first reported in 1975 by Osterman and Westerberg. It has been suggested that paroxysmal itching may be due to the activation of axons in CNS via abnormal synapses between demyelinated axons. Carbamazepine, phenytoin, and ibuprofen are known to be effective in the treatment of paroxysmal itching. We report a case of paroxysmal itching of 4 months' duration in a 41-year-old female with multiple sclerosis who suffered from severe paroxysmal itching on the left side of her neck and chest. The itching did not respond to carbamazepine, but it was partially controlled with ibuprofen.
