Genetic influence and heritability in mandibular prognathism of Korean families.
10.5125/jkaoms.2010.36.6.502
- Author:
Young Ho KIM
1
;
Han Young CHO
;
Chae Hwan BAEK
;
Ah Young LEE
;
Gunjong KIM
;
Whi Young KIM
;
Young Ju SUH
;
Seung Hak BAEK
;
Jongrak HONG
;
Jun Young PAENG
Author Information
1. Department of Orthodontics, the Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Mandibular prognathism;
Genetic influence;
Epidemiologic investigation;
Heritability
- MeSH:
Female;
Humans;
Male;
Malocclusion;
Orthognathic Surgery;
Pedigree;
Prognathism;
Surveys and Questionnaires
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2010;36(6):502-507
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
INTRODUCTION: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families. MATERIALS AND METHODS: Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49) probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center. RESULTS: The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were 81.2degrees, 84.1degreesand -2.9degrees, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability (h2, Falconer'method) was estimated to be 29.8% (0.298+/-0.059) in first-degree relatives. CONCLUSION: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion.
